In 2023, the 8th edition of the GIRP Supply Chain Conference will take place in Madrid, Spain where it will aim at tackling the multifaceted transformation and transition underpinning the core of the pharmaceutical supply chain. While the past years allowed us to draw critical lessons from the COVID-19 pandemic, many challenges still lay ahead, be it the green transition that is now in the spotlight of all the regulators, the digitalisation of the sector that is full of opportunities, or even the overall need to increase the resilience of structures and infrastructures for future crises.